Parkinson’s Disease and Microbiome

“Gut microbe mix may spark Parkinson’s’

Science News Magazine online article

December 1, 2016


This article describes several studies which, together, suggest that Parkinson’s disease is caused by the intestinal microbiome when it has a specific composition. It was found that the gut microbiome of diseased patients caused alpha-synuclein, the substance present in Parkinson’s patients, to clump in the brain compared to the gut microbiome of a healthy person transferred to mice with high levels of alpha-synuclein. In the second case, the mice did not show as many symptoms and the alpha-synuclein did not clump in the brain (this is what is believed to cause Parkinson’s disease).

We have discussed ideas of the human microbiome determining overall health. This has to do with the “ubiquity of microbes’, meaning they are found in all types of environments. We know that the bacteria in our gut produce byproducts while helping us break down and process our food. It is very interesting that they might be able to send signals to our brains. It seems like microbes must gain something beneficial by sending signals to the brain to make the organism act in a way that helps the microbe gain what it wants. We talked a little bit about microorganisms that infect insects to control them. The article was a summary of several peer-reviewed studies so I think they are credible. This is written in a very good way to communicate science to the general public since that is the purpose of this magazine. It pulls only the important parts of the methods and results to make it easy for the reader but also gives you enough information to critically think about it.

This topic makes me question many things like: What kind of chemical signals could microbes send to the brain to cause the symptoms of Parkinson’s disease? Is it a byproduct of their way of living or is it an intentionally released signal?